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BBR demonstrates robust anti-obesity effects in both preclinical and clinical settings [4, 47, 175, 222, 223]

Health authorities discourage its use due to insufficient human safety data, and some jurisdictions have restricted it as a prescription-only medicine despite it not being available through legitimate prescriptions

In conclusion, the role of betaine in rodents with NAFLD seems to involve multiple metabolic pathways, and its important role is to regulate the expression of genes involved in fatty acid and lipid metabolism, thus improving the development of liver steatosis

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For patients who have plateaued on maximum-dose semaglutide, switching to tirzepatide is the most evidence-backed next step